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Tryptamine, also known as 2-(1H-indol-3-yl)ethanamine, is a naturally occurring alkaloid and derivative of the common amino acid tryptophan. It is a secondary metabolite of L-tryptophan, and in the body, digestive enzymes convert tryptophan into tryptamine, releasing CO2 gas as a byproduct [1]. Further research has shown that tryptamine therefore occurs as a common metabolite in most living organisms [2]. It has no pharmacological activity whatsoever; tryptamine, when administered to humans, is rapidly metabolized by monoamine oxidase enzymes (the same enzymes which metabolize DMT) [3].


Research in organic chemistry shows that tryptamine can be synthesized starting with tryptophan as a precursor [4]. Tryptophan can be successfully utilized in a lab to prepare synthetic tryptamine. The general synthetic route uses a ketone or aldehyde as a catalyst, such as acetone and methyl ethyl ketone, which improves yields and speeds up the process. The ketone/aldehyde will form an imine with tryptophan, protecting the amine group from oxidation while it is decarboxylating. When heated to a boil under reflux, the tryptophan will thermally decarboxylate into tryptamine, releasing CO2 gas. The resulting tryptamine can be recovered and isolated using an extraction process. The yields can be quantitatively high and can range up to 70-90%, using certain ketone catalysts (such as spearmint oil or acetophenone). [5]


This compound is not for human consumption and is meant for research purposes ONLY. Currently available as the freebase.


[1] – https://www.brenda-enzymes.org/enzyme.php?ecno=

[2] – https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793(75)80963-X

[3] – https://pubmed.ncbi.nlm.nih.gov/3094536/

[4] – https://erowid.org/archive/rhodium/chemistry/tryptophan.html

[5] – https://chemistry.mdma.ch/hiveboard/rhodium/tryptamine.takano.html

Purity Analysis

BLANK-61-54-1 HPLC
61-54-1 HPLC
61-54-1 HNMR in CDCL3