Ketanserin is a selective and reversible antagonist of the serotonin, dopamine and adrenergic receptors. It is prescribed as an anti-hypertensive medicine in some countries, especially as an adjunct to chemotherapy, usually in 10 mg, 20 mg and 40 mg tablets.
Ketanserin is a serotonin antagonist, which means that it binds to and inhibits (deactivates) the serotonin receptors. It is able to block or reverse the effects of LSD and psilocybin in humans. This is analogous to how naloxone, an opioid antagonist, blocks or reverses the effects of opioid agonists, such as morphine, when administered to users.
Based on this evidence, ketanserin may be an effective treatment for reversing the effects of serotonin agaonists. It has potential as a harm reduction tool, being well-established as a safe treatment and being widely approved in human clinical trials involving healthy volunteers. Like how naloxone can reverse an opioid overdose, ketanserin is able to reverse the effect of a psychedelic by blocking the serotonin receptors which psychedelics bind to.
This compound is NOT for human consumption and is strictly for research purposes ONLY. Available as the tartrate salt.