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Isoproscaline, also known as 3,5-dimethoxy-4-isopropoxyphenethylamine, is a novel mescaline homolog originally discovered in 1986 by David E. Nichols (1). It has also been explored further in research by Alexander Shulgin and Ann Shulgin (2).


It is the 4O-isopropyl homolog of mescaline, and binds similarly to the serotonin receptors. It seems to have increased potency by weight, with an active dose in humans reported to be 50-80 mg (compared to 300-400 mg for mescaline).


This compound is NOT for human consumption and is available for research purposes ONLY. Available as the hydrochloride salt.


(1) – Nichols, D E. “Studies of the Relationship between Molecular Structure and Hallucinogenic Activity.” Pharmacology, Biochemistry, and Behavior, U.S. National Library of Medicine, Feb. 1986, www.ncbi.nlm.nih.gov/pubmed/3952123.

Web link: https://www.sciencedirect.com/science/article/abs/pii/009130578690362X

(2) – Shulgin, Alexander T., and Ann Shulgin. Pihkal: a Chemical Love Story. Transform Press, 2019.

Web link: https://erowid.org/library/books_online/pihkal/pihkal.shtml#index

Purity Analysis



Isoproscaline MSDS

COA (Certificate of Analysis)

Isoproscaline COA