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Baicalein, aka 3,4,5-trihydroxyflavone, is a naturally-occurring phenolic flavone isolated from the plant Scutellaria baicalensis. It is similar in pharmacophore to other flavones such as apigenin, K36, and baicalin (the latter of which is a less bioavailable prodrug for baicalein). Various flavone derivatives appear to display similar in vitro binding affinity to benzodiazepenes at the BZD-specific GABAnergic binding sites. This results in the increase of ionic current caused by chloride flow from the ligand gated channels. Animal studies have confirmed its action as a positive allosteric modulator of the GABAnergic site and it has shown to substitute for benzodiazepenes in rat discrimination studies. Baicalein is also shown to have neuroprotective effects against beta-amyloid proteins in vitro , anticarcinogenic effects in vitro , and is a known potent inhibitor of viral mRNA transcriptases, including those for HIV .
This compound is NOT intended for human consumption, and is for laboratory reagent or forensic/analytical purposes ONLY. The intent of its sale is agrochemical and other agricultural research.
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