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alpha-GPC, aka alpha-glycerylphosphorylcholine, is a naturally occurring alkaloid and a prodrug for choline. It is a metabolic intermediate in the biological production of the neurotransmitter acetylcholine, as well as phosphatidylcholine (which is a phospholipid used by the body in the creation of cellular membranes). It is produced naturally in the human body from choline itself. Alpha-GPC is a bioavailable prodrug and can elevate endogenous levels of choline. Each mole of alpha-GPC metabolizes into equimolar ratios of choline, phosphate, and glycerol.

Placebo controlled, human clinical trials demonstrate alpha-GPC to be effective in alleviating symptoms of cognitive decline in patients with Alzheimer’s disease, cerebral ischemia, vascular dementia, and stroke [3]. Choline (as well as its prodrugs) can reduce the risk of neural tube defects in pregnant women [4] [5], and low-choline diets are associated with pre-eclampsia, premature birth, and low birth weight [1]. In healthy subjects, alpha-GPC (supplemented alongside caffeine) has been shown to improve test scores and reaction times during acute stress [6].

A human clinical trial conducted by MiT professor Richard Wurtman found that choline, in combination with docosahexanoic acid (an omega-3 fatty acid from fish oil) and uridine (a nucleoside from RNA) consistently alleviated symptoms of Alzheimer’s in diagnosed patients [7].

This compound is NOT meant for human consumption whatsoever. Our product is not meant for nutritional supplementation, in vivo or veterinary research, and is provided either for in vitro research or as an analytical/reagent standard ONLY. The research provided above is not meant to endorse consumption of our product, but for educational purposes. Our product is alpha-GPC compounded with 43.5-48.5% dicalcium phosphate dihydrate by mass.

[1] – Zeisel SH; da Costa KA (November 2009). “Choline: an essential nutrient for public health”. Nutrition Reviews. 67 (11): 615–23. Web.

[2] – Fischer, L. M., K.-A. Da Costa, L. Kwock, J. Galanko, and S. H. Zeisel. “Dietary choline requirements of women: effects of estrogen and genetic variation.” American Journal of Clinical Nutrition 92.5 (2010): 1113-119. Web.

[3] – Parnetti, Lucilla, Francesco Amenta, and Virgilio Gallai. “Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data.” Mechanisms of Ageing and Development 122.16 (2001): 2041-055. Web.

[4] – Shaw, G. M., S. L. Carmichael, W. Yang, S. Selvin, and D. M. Schaffer. “Periconceptional Dietary Intake of Choline and Betaine and Neural Tube Defects in Offspring.” American Journal of Epidemiology 160.2 (2004): 102-09. Web.

[5] – Rees W, Wilson F, Maloney C. Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr. 136 (2006): 1701S–1705S. Web.

[6] – Hoffman, Jay R., Nicholas A. Ratamess, Adam Gonzalez, Noah A. Beller, Mattan W. Hoffman, Mark Olson, Martin Purpura, and Ralf Jäger. “The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students.” Journal of the International Society of Sports Nutrition 7.1 (2010): 39. Web.

[7] – Trafton, Anne. “Nutrient Mixture Improves Memory in Patients with Early Alzheimer’s.” MIT News, 9 July 2012,

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