Aceglutamide

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Description

L-aceglutamide, also known as N-acetyl-L-glutamine or neuramina, is an amino acid and synthetic analog of L-theanine, L-glutamine and L-glutamic acid. It acts as a metabolic prodrug for L-glutamine, N-acetyl-L-glutamate, and L-glutamate.

L-aceglutamide is typically prescribed as a treatment for dementia, Alzheimer's or cerebral trauma (such as infarction or ischemia arising from a stroke). It is also prescribed occasionally as a psychostimulant in the treatment of mental health disorders, under the brand name Neuramina. It is also prescribed (as the aluminum salt) for the treatment of peptic ulcers and gastritis [1]. L-aceglutamide itself demonstrates activity as an anti-inflammatory and moderate analgesic, similar to L-proglumide (another synthetic glutamine analog prescribed for similar purposes) [2].

L-aceglutamide is often combined with safflower extract (which contains the anti-inflammatory drugs N-(p-coumaroyl)serotonin and N-feruoylserotonin) in China for a medicinal treatment called Guhong injection, which is being developed to treat patients with cerebral trauma or MCI (mild cognitive impairment) from early-stage dementia or Alzheimer's [3] [4]. It is being currently researched for other applications, such as the treatment of lung cancer [5] and diabetes [6].

This compound is NOT for human consumption and is strictly for research purposes ONLY. Available as the free acid.

 

[1] - https://www.ncbi.nlm.nih.gov/pubmed/1790087

[2] - https://www.ncbi.nlm.nih.gov/pubmed/7257951

[3] - https://www.ncbi.nlm.nih.gov/pubmed/27624481

[4] - https://www.ncbi.nlm.nih.gov/pubmed/29867497

[5] - https://patents.google.com/patent/CN101120959A/en

[6] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717862/