L-aceglutamide, also known as N-acetyl-L-glutamine or neuramina, is an amino acid and analog of L-theanine, L-glutamine and L-glutamic acid.
Aceglutamide occurs naturally in humans  and is likely ubiquitous to all living organisms, since it is a known metabolite of the essential amino acid glutamine. It has improved bioavailability over glutamine itself and can
penetrate the blood-brain barrier more easily, therefore having increased oral potency and improved effects. It is more effective than orally consuming glutamine itself. According to the Human Metabolome Database, "[aceglutamide] is used for parenteral nutrition as a source of glutamine since glutamine is too unstable whereas [aceglutamide] is very stable." Due to it being a prodrug for glutamine itself, the body must undergo another step of metabolism (deacetylation) in order to decompose it, therefore it lasts much longer in the body upon consumption, and has a longer half-life.
L-aceglutamide is typically prescribed as a treatment for dementia, Alzheimer's or cerebral trauma (such as infarction or ischemia arising from a stroke). It is also prescribed occasionally as a psychostimulant in the treatment of mental health disorders, under the brand name Neuramina. It is also prescribed (as the aluminum salt) for the treatment of peptic ulcers and gastritis . L-aceglutamide itself demonstrates activity as an anti-inflammatory and moderate analgesic, similar to L-proglumide (another synthetic glutamine analog prescribed for similar purposes) .
L-aceglutamide is often combined with safflower extract (which contains the anti-inflammatory drugs N-(p-coumaroyl)serotonin and N-feruoylserotonin) in China for a medicinal treatment called Guhong injection, which is being developed to treat patients with cerebral trauma or MCI (mild cognitive impairment) from early-stage dementia or Alzheimer's  . It is being currently researched for other applications, such as the treatment of lung cancer  and diabetes .
This compound is NOT for human consumption and is strictly for research purposes ONLY. Available as the free acid.
 - http://www.hmdb.ca/metabolites/HMDB0006029
 - https://www.ncbi.nlm.nih.gov/pubmed/1790087
 - https://www.ncbi.nlm.nih.gov/pubmed/7257951
 - https://www.ncbi.nlm.nih.gov/pubmed/27624481
 - https://www.ncbi.nlm.nih.gov/pubmed/29867497
 - https://patents.google.com/patent/CN101120959A/en
 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717862/