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5-methoxytryptamine, also known as mexamine, or 2-(5-methoxy-1H-indol-3-yl)ethanamine, is a naturally occurring alkaloid and tryptamine derivative. It is chemically similar to many other common compounds including:

  • melatonin (5-methoxy-N-acetyltryptamine)
  • serotonin (5-hydroxytryptamine)
  • 5-HTP (5-hydroxytryptophan)

It is commonly found endogenously (i.e. in humans) as a metabolite of serotonin and melatonin.

Research in organic chemistry shows that 5-methoxytryptamine can be synthesized starting with melatonin as a precursor [1] [2]. Hydrolysis can occur using NaOH with the presence of sodium dithionite as a mild reducing agent, preventing oxidation of 5-methoxytryptamine.


This compound is not for human consumption and is meant for research purposes ONLY. Currently available as the freebase.


[1] – https://patents.google.com/patent/US4772726A/en

[2] – https://erowid.org/archive/rhodium/chemistry/mexamine.html

Purity Analysis

Blank 608-07-1 HPLC
608-07-1 HPLC