Substituted Indoles

All compounds with indole rings.

This broader category refers to all compounds with indole rings. It may include alkaloids like tryptamines and lysergamides. Alternately, it also includes amino acids like L-tryptophan, L-abrine, or other derivatives and natural isolates, such as diindolylmethane. Nonetheless, a wide variety of substituted indoles are known to have psychoactive properties with binding affinity to the serotonergic receptors. This 5HT-agonist-induced activity was once thought to be a psychotomimetic model, which could be used as a controlled model of psychosis, but this theory was later dismissed, and serotonergic agonists later gained popularity as adjuncts for psychotherapy [1]. According to Majic et. al, serotonergic indoles have a “range of recent clinical applications” which include treatments for “cluster headaches and obsessive-compulsive disorder to addiction and the treatment of fear and anxiety inpatients suffering from terminal illness” [1].


Substituted Indoles listed here are not available for in vivo research or for consumption.

[1] – Majić, Tomislav, Timo T. Schmidt, and Jürgen Gallinat. “Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?” Journal of Psychopharmacology 29.3 (2015): 241-53. Web.