This broader category refers to all compounds with indole rings. It may include alkaloids like tryptamines and lysergamides. Alternately, it also includes amino acids like L-tryptophan, L-abrine, or other derivatives and natural isolates, such as diindolylmethane. Nonetheless, a wide variety of substituted indoles are known to have psychoactive properties with binding affinity to the serotonergic receptors. This 5HT-agonist-induced activity was once thought to be a psychotomimetic model, which could be used as a controlled model of psychosis, but this theory was later dismissed, and serotonergic agonists later gained popularity as adjuncts for psychotherapy . According to Majic et. al, serotonergic indoles have a “range of recent clinical applications” which include treatments for “cluster headaches and obsessive-compulsive disorder to addiction and the treatment of fear and anxiety inpatients suffering from terminal illness” .
Substituted Indoles listed here are not available for in vivo research or for consumption.
 – Majić, Tomislav, Timo T. Schmidt, and Jürgen Gallinat. “Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?” Journal of Psychopharmacology 29.3 (2015): 241-53. Web.